CONCEPT OF LIFELONG HEALTH = PREVENTION OF CHRONIC METABOLIC DISEASE
Muhammad Usman Naeem, Abdul Ghani MD
Unhealthy food and the lack of exercise produce unhealthy chemicals that lead to chemical pathways and cascades which produces what I call the Axes of Damage:
- Inflammation
- High glucose that causes cross linking with different proteins and making them dysfunctional also producing diabetes.
- High cholesterol causes atherosclerosis, leading to heart disease and stroke.
- High angiotensin 2 that causes HTN, enlarged heart, damage blood filtering units (nephrons) of the kidney, leading to kidney disease.
- Sticky platelets.
The CMD are treated mostly with medicine with little or no emphasis on eating healthy food and exercising. Some of the medicines are costly and the patients cannot afford them. This results in the under-treatment of the disease, which allows it to progress. Consequently, the disease can become severe and lead to complications such as heart failure from hypertension (HTN). The harmful substances found in unhealthy food, combined with a lack of exercise, cannot be fully addressed through medication alone, as there aren’t enough medications to counteract these effects. Relying solely on medication without adopting a healthy diet and exercise regimen creates gaps in the management of chronic medical conditions. This ultimately contributes to the worsening of the disease and its associated complications.
The Chain Reaction does not mean everybody gets all of these diseases one may get HTN and nothing else while another may develop dementia at the end of his life, but it is a good concept to understand the mechanisms of the different CMD. Lag period (Incubation period) A person starts developing arterial plaques at the age of 20 people but develops heart disease in his 50s. He does not make connection between an unhealthy lifestyle and heart disease, but 30 years is enough time to prevent heart disease. Most cancers and dementia occur in a person’s 60s, 70s and 80s but these start in the 30s. There is no medicine for dementia. The treatment of cancer is costly. These choices are not perfect but have a lot of side effects. There is a lot of time to prevent most of the cancers and dementia.
Factoring the risk factors:
HTN and diabetes mellitus are considered risk factors for heart disease and kidney discase, actually heart disease and kidney disease can start without HTN and diabetes.
Two important Points:
- CMD’s are preventable diseases.
- Two organs that are vulnerable to unhealthy foods and lack of exercise are the brain and the pancreas. Diabetes has moved from middle and old age to young age. Dementia is more common than in the past while depression is the most common disease on the planet.
Disease causing Disease CHF (congestive heat failure) is caused by damaged heart because of a heart attack or a long-standing HTN. Kidney failure occurs because of uncontrolled diabetes and uncontrolled HTN. Healthy food and exercise can prevent CMD and its complications or at least slow the disease and its complications. In the chain reaction, one disease does not cause the next disease. All the diseases are caused by the Axis of Damage. Yes, one disease can bring the next disease early (because the first disease occurred from the lack of prevention). A person without HIN and DM may develop atherosclerosis with LDL of 140 mg, but with HTN or DM, it may require LDL cholesterol of 120 mg. So, each disease in the Chain Reaction lowers the threshold of the next one.
- Spoilers
- Stress
- Smoking
- Lack of fruits and vegetables
Lack of exercise (could bring CMD diseases early) because of inflammation and lack of anti-inflammatory chemicals. A smoker who eats fruits and vegetables and who exercises is less likely to have lung cancer than one who smokes but does not eat fruits or vegetables and does not exercise. Different models help a person understand and deal with CMD:
Number Model
BP 140/90 mg or above is HTN; Below 140 / 90 mg is not. Stiffness of the heart muscle and the arterial wall starts before BP reaches 140/ 90. This is caused by unhealthy food in the lack of exercise before the BP goes up. This is called HTN.High risk Low risk Model
High-risk patients are treated aggressively fair enough. The low-risk patient is treated conservatively; eventually the low-risk becomes high risk. Most of the heart attacks, Strokes and cancers come from low to moderate risk patients because the pools of the low to moderate risk are large. With unhealthy food and the lack of exercise, everybody is at risk.Prevention Model (River Model)
Unhealthy food, the lack of exercise, and smoking are Upstream.
CMD and its complications require Medical Procedures and gadgets and are all downstream.Symptoms Model
Unhealthy food and the lack of exercise start the Axes of Damage.
The Axes start the disease processes that bring numbers up (BP of 140 / 90 mg and a HbA1c of 6.5). This brings a “name” to numbers (like HTN and diabetes) then after the disease is established, it may take another 5 to 10 years before symptoms appear. A person with BP of 150/ 100 mg or an HbA1c of 7.0 may be walking around without any symptoms. Kidney disease up to level 5 may not produce symptoms. Level 6 is kidney failure. If insurance deductibles go up, a person may not see the physician before he has symptoms. A person could feel fine one day before a heart attack.Bug Model
An infection is treated with an antibiotic. HTN and DM are treated with medicines. The patient wants pills. ” Give me the pill.” “Give me the shot?” Folks need to be taught the value of healthy food and exercise. Insulin and some other maintenance drugs are very costly.
The patient must take them for the rest of his life that leads to under treatment of disease and emergence of other CMD.Food Model
There is no food model. Cutting fat, salt, and sugar is not enough.
The rise in glucose after medicines is not discussed with the patient.
Value of fiber is not reviewed. There is so much craving caused by salt, sugar, and fat, but the patient is simply told to cut down the calories. The synergy between exercise and healthy foods is not discussed. Some folks spend their lives and fortunes trying to lose weight through different “diets” without exercise, they seldom lose the weight.
Illiteracy about Health and Healthcare
The public knows instinctively what healthy food is, but folks go for taste, price, and easy availability. The patient finds out about healthcare (which medicine is covered, which is not covered, what procedure is needed, and what insurance will approve) when he gets a disease. Humira is a $4,500 a month injection. If insurance is not good, a patient is not going to get the medicine.Progression of a Disease
In spite of 30+ medicines to control HTN, one third of HTN is not adequately treated. WHY? Because healthy food and exercise are not instituted in a treatment that leads to the progression of HTN that leads to an enlarged heart, irregular heart rhythm, and kidney disease.Invincibility, Susceptibility, and Responsibility
A 40-year-old man eating chicken wings, pizza, fries, and drinking soft drinks feel invincible. He does not know that he is in the lag period of heart disease and maybe cancer or even dementia. He believes,” My doctor will keep me healthy.” He should believe,” Healthy food, exercise and probably my doctor will keep me healthy?” A 30-year-old holds the key to his own health and prevention of CMD.Dementia
No therapeutic window is available for dementia. This disease occurs in 60 – 70-year-olds. There is no treatment, but it can be prevented.Laboratory Testing
A lab test can help a person prevent CDM:
- Earlier in life, every adult should have these tests yearly.
- LDL cholesterol- should be 100 or less
- HDL cholesterol- should be 55 or more
- TG- should be 120 or less
- HbA1c- should be 5.7% or less
- CRP- should be less than 1 mg
Citation list
- ENDO, A. (2010). A historical perspective on the discovery of Statins. Proceedings of the Japan Academy, Series B, 86(5), 484–493. https://doi.org/10.2183/pjab.86.484
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Abdul Ghani
Dr. Abdul Ghani is an endocrinologist in Zephyrhills, Florida. He earned his medical degree from King Edward Medical University and completed his Internal Medicine residency at Cook County Hospital in Chicago, Illinois. With over 40 years of practice, Dr. Ghani specializes in treating chronic diabetes, hypertension, obesity, and hyperlipidemia. An avid reader, he possesses a thorough understanding of human diet and the benefits of exercise.