Walking and Vegetables
Muhammad Usman Naeem, Abdul Ghani MD
Walk to remember and remember to walk.
The hippocampus, embedded deep into temporal lobe stores the memory. All the problems we experience and fear stem from memory. The hippocampus receives its blood supply through capillaries, which are the smallest blood vessels. To maintain the health of the hippocampus, it is important to protect the capillaries. High blood glucose, inflammation, hypertension (HTN), and fat can all have a significant impact on the health of capillaries [1]. Walking 2-3 miles a day can help improve the health of your capillaries. Walking not only lowers blood glucose and triglycerides but increases HDL levels, also known as “good” cholesterol [2]. It also aids in maintaining the slippery and smooth lining of the arteries, reducing the likelihood of white blood cells and platelets adhering to the artery walls and leading to blood clots or inflammation. In addition, physical activity also causes the smooth muscle cells in the middle layer of the artery wall to relax, aiding in the maintenance of open arteries and the prevention of spasms.We must walk to develop new capillaries to replace lost ones, a process called angiogenesis. Research has shown that exercise can stimulate the growth of new blood vessels in the skeletal muscles of individuals with hypertension [3]. The brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor family, is primarily produced by nerves located in working muscles within the brain. During exercise, BDNF plays an essential role in promoting muscle regeneration and enhancing neuromuscular junctions. Moreover, BDNF increases neurogenesis by affecting cell viability and proliferation [4]. The modification of synaptic connections is important for storing memories.
Vegetables
Vegetables contain dietary fiber, also known as roughage or bulk, which is the indigestible part of plant foods. When consumed, it is fermented by the acidic pH of the colon and produces short-chain fatty acids (SCFA) [5]. SCFAs also influence several cell types to control essential biological functions such as intestinal activity, immune response, and host metabolism. Their impact extends to the activity and future of immune cells [6]. SCFA also produces a precursor of Serotonin. The precursor goes to the brain and converts into serotonin. In mature individuals, serotonin reuptake inhibitors and activate receptors to decrease anxiety-related behaviors and stimulate neurogenesis.Eating a variety of vegetables supports the well-being of our digestive system by promoting the proliferation of gut bacteria, particularly the beneficial, healthy bacteria. These gut bacteria create additional padding within the colon wall to remain inside without consuming sufficient vegetables, there won’t be additional cushioning for the bacteria lining the colon, and they can escape. Research shows that despite the proven benefits of consuming vegetables, Americans do not consume adequate fruits and vegetables [7].
A leaky bowl cannot be diagnosed by colonoscopy or CT scan of the colon. When bacteria leak out of the colon, they often enter the bloodstream. The liver directly receives blood from the intestines, exposing it to intestinal bacteria. Research shows a link between gut bacteria and nonalcoholic fatty liver disease (NAFLD). Around 10–20% of individuals with NAFLD progress to endotoxins and nonalcoholic steatohepatitis (NASH) are generated by Gram-negative bacteria that could play a vital role in NAFLD pathogenesis [8]. Gut bacteria that leak into the blood can also cross the blood-brain barrier and infect the brain, leading to memory and executive function impairment, which can cause dementia [9]. Hence, “By walking 2-3 miles a day and consuming vegetables, we can preserve the memory”
The gut bacteria create an ecosystem known as the gut microbiome. Vegetables originate from plants that are exposed to rainwater and insects during pollination. They are part of Cosmo (the Greek term for the entire universe). Therefore, through our bacteria, we are interconnected with the natural world and we are in harmony with it (due to our immunity and satiety).
Citation list
- Petrie, J. R., Guzik, T. J., & Touyz, R. M. (2018). Diabetes, hypertension, and cardiovascular disease: Clinical insights and vascular mechanisms. Canadian Journal of Cardiology, 34(5), 575–584. https://doi.org/10.1016/j.cjca.2017.12.005
- Franczyk, B., Gluba-Brzózka, A., Ciałkowska-Rysz, A., Ławiński, J., & Rysz, J. (2023). The impact of aerobic exercise on HDL quantity and quality: A narrative review. International Journal of Molecular Sciences, 24(5), 4653. https://doi.org/10.3390/ijms24054653
- Gliemann, L., Gunnarsson, T. P., Hellsten, Y., & Bangsbo, J. (2014). 10‐20‐30 training increases performance and lowers blood pressure and vegf in runners. Scandinavian Journal of Medicine & Science in Sports, 25(5). https://doi.org/10.1111/sms.12356
- Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Heo, S., McLaren, M., Pence, B. D., Martin, S. A., Vieira, V. J., Woods, J. A., McAuley, E., & Kramer, A. F. (2010). Brain-derived neurotrophic factor is associated with age- related decline in hippocampal volume. The Journal of Neuroscience, 30(15), 5368–5375. https://doi.org/10.1523/jneurosci.6251-09.2010
- den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013). The role of short- chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research, 54(9), 2325–2340. https://doi.org/10.1194/jlr.r036012
- Liu, X., Shao, J., Liao, Y.-T., Wang, L.-N., Jia, Y., Dong, P., Liu, Z., He, D., Li, C., & Zhang, X. (2023). Regulation of short-chain fatty acids in the immune system. Frontiers in Immunology, 14. https://doi.org/10.3389/fimmu.2023.1186892
- Dittus, K. L., Hillers, V. N., & Beerman, K. A. (1995). Benefits and barriers to fruit and vegetable intake: Relationship between attitudes and consumption. Journal of Nutrition Education, 27(3), 120–126. https://doi.org/10.1016/s0022-3182(12)80802-8
- Kessoku, T., Kobayashi, T., Tanaka, K., Yamamoto, A., Takahashi, K., Iwaki, M., Ozaki, A., Kasai, Y., Nogami, A., Honda, Y., Ogawa, Y., Kato, S., Imajo, K., Higurashi, T., Hosono, K., Yoneda, M., Usuda, H., Wada, K., Saito, S., & Nakajima, A. (2021). The role of leaky gut in nonalcoholic fatty liver disease: A novel therapeutic target. International Journal of Molecular Sciences, 22(15), 8161. https://doi.org/10.3390/ijms22158161
- Zou, B., Li, J., Ma, R.-X., Cheng, X.-Y., Ma, R.-Y., Zhou, T.-Y., Wu, Z.-Q., Yao, Y., & Li, J. (2023). Gut Microbiota is an impact factor based on the brain-gut axis to alzheimer’s disease: A systematic review. Aging and Disease, 14(3), 964. https://doi.org/10.14336/ad.2022.1127
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Muhammad Usman Naeem
Muhammad Usman Naeem is a pre-medical student with a Bachelor’s degree in Biomedical Sciences from the University of South Florida. His primary interests are in neuro-oncology and preventive medicine. Muhammad is actively researching the role of MR1 - Major Histocompatibility Complex Class I-related gene in cancer immunotherapy. Additionally, he has experience working with elderly patients, managing a range of chronic diseases including diabetes, hypertension, and cardiovascular disease.
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