Dignity of Human Brain
Muhammad Usman Naeem, Abdul Ghani MD
Brain of Mind
The brain is the organ, and the mind is what the brain does. The human brain is the most complex object found in known nature. It is an extremely heterogeneous tissue which answers for its complexity. Each part of the brain has its functional activity and a unique developmental characteristic. However, the different parts function as a single organ. According to recent studies, the central nervous system (CNS) contains about 100 billion nerve cells and each nerve cell holds the capacity to make up to 10,000 synaptic interconnections [1]. The human brain weighs 2% of the body weight but uses 10% of the body’s oxygen and 20% of glucose [2]. This high demand for glucose is essential for the brain to perform its executive functions including decision-making, social cognition, happiness, and learning.
Decision making
Throughout our lives, we are constantly faced with choices, some holding the power to shape our future, while others seem trivial. The prefrontal cortex (decision-making) connects with the amygdala (emotions) to evaluate and regulate reactions before acting on them, which helps manage emotions during amygdala hijack. What connects these two parts of the brain are omega- 3 fatty acids. The healthy rate of omega-6 to omega-3 fatty acids in the brain are 4:1 [3]. According to recent studies, American food contains roughly17:1 which means Omega-6 (pro inflammatory) is 17 times more than omega-3 (anti-inflammatory) [4]. This imbalanced ratio of omega-6 to omega-3 fatty acids keeps our decision- making unconnected with our emotions and we make spur of the moment without understanding the consequences. People struggle to make optimal decisions due to the high computational requirements. A healthy diet with rich omega-3 fatty acids will yield reasonable decisions in a reasonable time frame.
Brain organ of consultation
The human brain is a social organ. Emotional connectivity is an essential core of being human. We need each other from day one for our mental growth. Our initial reaction is to avoid people especially if we are raised with fewer friends or relatives. Attending school is beneficial because it allows us to learn while our parents are occupied with work. Then we have family gatherings. If parents are busy, we have uncles, aunts, and cousins. We befriend some and fight others, but our brain continues to grow. We also need to have restrictions in place until we are fully grown, like in our mid-twenties. The first set of restrictions comes from parents then religion, family, traditions, teachers, and society in general. We learn from everybody what is good and what is not.
Life liberty and pursuit of happiness
Happiness in America is sex and money. They are addictive. There are no restrictions from parents, teachers, and friends. With social media, we are constantly inundated with information, but we don’t have restrictions. We do not have any brakes. Our brain is not used to pictures. For millennia, our brains have been accustomed to seeing people, listening to stories, and interpreting facial expressions, but now, all that has changed. It’s all loneliness in a way now. It is the “me” generation, not the “us” generation. Our brain is lonely and with a lot of lies and disinformation coming we need friends. In-person friends, not screen friends.
What is happiness at 18?
At the age of 18, we graduate from high school, marking the beginning of independent thinking. We have a lot of energy, but our brain is not fully developed. Big engine but no breaks. It is time for some supervision and guidance. This is the time for debates and projects to express, collaborate, face challenges, and find solutions. The brain develops executive function e.g. decision-making. While working with elders we learn how to take responsibility. It is often discussed whether is college necessary and the answer is yes. Because at age 18, we graduate from high school, we enter college and delay marriage. We help our brains to continue growing. If we don’t go to college, we are likely to start smoking, get married, smoke marijuana, drink alcohol and opioids. In Deaths of Despair and the Future of Capitalism by Anne Case and Angus Deaton. There is a correlation between the absence of college education and opioids, alcoholism, and suicides [5]. With college, you almost escape them. College education is important.
Learning
The brain only grows when it receives new information. When we learn something new, certain parts of the brain change and grow larger, just like muscles. Our brain forms new connections and makes existing neural pathways stronger. These changes are also known as “Neuroplasticity” [6]. The ability to speak a second language is always beneficial as it can make us more sociable. During pre-Islamic times, a 17-year-old boy traveled with his father in a caravan, learning how adults talk and how to prepare for travel. He listened to the stories. Stories stretched his imagination and created possibilities. He learned how to wield a sword, shoot an arrow, and throw a spear. Why? Because of the rules of war. If he loses the war, he might die. If he survives, his mother and sister could be captured by the enemy the very next day. He did have executive functions. Modern 17 years wouldn’t measure up to him. The prefrontal cortex (executive function) and hippocampus: (memory) are the latest in human development [7]. As per the theory of evolution, what comes first will be the last to go, and what comes last will be the first to go. That makes executive function and memory very vulnerable to disease. The most important areas of the brain are most sensitive to disease. Before we lose memory, we lose executive function [8]. One sign of oncoming dementia is we stop planning. Build extra so we can afford to lose. We should continue learning as adults. Engage in debates and take on various projects. Participate in community service, listen to the wisdom of elders, and gain life-altering lessons. Write handwritten letters in a second language, one to grandma and one to mom. Travel to foreign countries and learn to cook new dishes. Research shows that learning a second language can help prevent dementia [9].
Citation list
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- Raichle, M. E., & Gusnard, D. A. (2002). Appraising the brain’s energy budget. Proceedings of the National Academy of Sciences, 99(16), 10237–10239. https://doi.org/10.1073/pnas.172399499
- Balić, A., Vlašić, D., Žužul, K., Marinović, B., & Bukvić Mokos, Z. (2020). Omega-3 versus omega-6 polyunsaturated fatty acids in the prevention and treatment of inflammatory skin diseases. International Journal of Molecular Sciences, 21(3), 741. https://doi.org/10.3390/ijms21030741
- Simopoulos, A. P. (2008). The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Experimental Biology and Medicine, 233(6), 674–688. https://doi.org/10.3181/0711-mr-311
- Case, A., & Deaton, A. (2021). Deaths of despair and the future of capitalism Anne case, Angus Deaton ; with a new preface by the authors. Princeton University Press.
- Mateos-Aparicio, P., & Rodríguez-Moreno, A. (2019). The impact of studying brain plasticity. Frontiers in Cellular Neuroscience, 13. https://doi.org/10.3389/fncel.2019.00066
- Preston, A. R., & Eichenbaum, H. (2013). Interplay of hippocampus and prefrontal cortex in memory. Current Biology, 23(17). https://doi.org/10.1016/j.cub.2013.05.041
- Hoshi, H., Hirata, Y., Kobayashi, M., Sakamoto, Y., Fukasawa, K., Ichikawa, S., Poza, J., Rodríguez-González, V., Gómez, C., & Shigihara, Y. (2022). Distinctive effects of executive dysfunction and loss of learning/memory abilities on resting-state brain activity. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-07202-7
- Kim, S., Jeon, S. G., Nam, Y., Kim, H. soo, Yoo, D.-H., & Moon, M. (2019). Bilingualism for dementia: Neurological mechanisms associated with functional and structural changes in the brain. Frontiers in Neuroscience, 13. https://doi.org/10.3389/fnins.2019.01224
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Muhammad Usman Naeem
Muhammad Usman Naeem is a pre-medical student with a Bachelor’s degree in Biomedical Sciences from the University of South Florida. His primary interests are in neuro-oncology and preventive medicine. Muhammad is actively researching the role of MR1 - Major Histocompatibility Complex Class I-related gene in cancer immunotherapy. Additionally, he has experience working with elderly patients, managing a range of chronic diseases including diabetes, hypertension, and cardiovascular disease.